Welcome back to our series of case studies of research funders using the Grant Linking System. In this interview, I talk with Cátia Laranjeira, PTCRIS Program Manager at FCCN|FCT, Portugal’s main public funding agency, about the agency’s approach to metadata, persistent identifiers, Open Science and Open Infrastructure.
With a holistic approach to the management, production and access to information on science, FCCN|FCT’s decision to implement the Grant Linking System within their processes was not simply a technical upgrade, but a coordinated effort to continue building a strong culture of openness. With the mantra “register once, reuse always”, FCCN|FCT efforts to embrace open funding metadata was only logical.
Repositories are home to a wide range of scholarly content; they often archive theses, dissertations, preprints, datasets, and other valuable outputs. These records are an important part of the research ecosystem and should be connected to the broader scholarly record. But to truly serve their purpose, repository records need to be connected to each other, to the broader research ecosystem, and to the people behind the research. Metadata is what makes that possible. Enhancing metadata is a way to tell a fuller, more accurate story of research. It helps surface relationships between works, people, funders, and institutions, and allows us as a community to build and use a more connected, more useful network of knowledge - what Crossref calls the ‘Research Nexus’.
The Crossref Grant Linking System (GLS) has been facilitating the registration, sharing and re-use of open funding metadata for six years now, and we have reached some important milestones recently! What started as an interest in identifying funders through the Open Funder Registry evolved to a more nuanced and comprehensive way to share and re-use open funding data systematically. That’s how, in collaboration with the funding community, the Crossref Grant Linking System was developed. Open funding metadata is fundamental for the transparency and integrity of the research endeavour, so we are happy to see them included in the Research Nexus.
Lots of exciting innovations are being made in scientific publishing, often raising fundamental questions about established publishing practices. In this guest post, Ludo Waltman and André Brasil discuss the recently launched MetaROR publish-review-curate platform and the questions it raises about good practices for Crossref DOI registration in this emerging landscape.
It’s here. After years of hard work and with a huge cast of characters involved, I am delighted to announce that you will now be able to instantly link to all published articles related to an individual clinical trial through the Crossmark dialogue box. Linked Clinical Trials are here!
In practice, this means that anyone reading an article will be able to pull a list of both clinical trials relating to that article and all other articles related to those clinical trials – be it the protocol, statistical analysis plan, results articles or others – all at the click of a button.
Linked Clinical Trials interface
Now I’m sure you’ll agree that this sounds nifty. It’s definitely a ‘nice-to-have’. But why was it worth all the effort? Well, simply put: “to move a mountain, you begin by carrying away the small stones”.
Science communication in its current form is an anachronism, or at the very least somewhat redundant.
You may have read about the ‘crisis in reproducibility’. Good science, at its heart, should be testable, falsifiable and reproducible, but an historical over-emphasis on results has led to a huge number of problems that seriously undermine the integrity of the scientific literature.
Issues such as publication bias, selective reporting of outcome and analyses, hypothesising after the results are known (HARKing) and p-hacking are widespread, and can seriously distort the literature base (unless anyone seriously considers Nicholas Cage to be causally related to people drowning in swimming pools).
This is, of course, nothing new. Calls for prospective registration of clinical trials date back to the 1980s and it is now becoming increasingly commonplace, recognising that the quality of research lies in the questions it asks and the methods it uses, not the results observed.
Uptake of trial registration year-on-year since 2000
Building on this, a number of journals and funders – starting with BioMed Central’s Trialsover 10 years ago – have also pushed for the prospective publication of a study’s protocol and, more recently, statistical analysis plan. The idea that null and non-confirmatory results have value and should be published has also gained increasing support.
Over the last ten years, there has been a general trend towards increasing transparency. So what is the problem? Well, to borrow an analogy from Jeremy Grimshaw, co-Editor-in-Chief of Trials – we’ve gone from Miró to Pollock.
Although a results paper may reference a published study protocol, there is nothing to link that report to subsequent published articles; and no link from the protocol itself to the results article.
A single clinical trial can result in multiple publications: the study protocol and traditional results paper or papers, as well as commentaries, secondary analyses and, eventually, systematic reviews, among others, many published in different journals, years apart. This situation is further complicated by an ever-growing body of literature.
Researchers need access to all of these articles if they are to reliably evaluate bias or selective reporting in a research object, but – as any systematic reviewer can tell you – actually finding them all is like looking for a needle in a haystack. When you don’t know how many needles there are. With the haystack still growing.
That’s where we come in. The advent of trial registration means that there is a unique identifier associated with every clinical trial, at the study-level, rather than the article level. Building on this, the Linked Clinical Trials project set out to connect all articles relating to an individual trial together using its trial registration number (TRN).
By adapting the existing Crossmark standard, we have captured additional metadata about an article, namely the TRN and the trial registry, with this information then associated with the article’s DOI on publication. This means that you will be able to pull all articles related to an individual clinical trial from the Crossmark dialogue box on any relevant article.
This obviously has huge implications for the way science is reported and used. By quickly and easily linking to related published articles, it will enable editors, reviewers and researchers to evaluate any selective reporting in the study, and help to provide far greater context for the results.
As all the metadata will be open access (CC0), with no copyright, it will also be possible to access this article ‘thread’ through the Crossref Metadata Search, or independently through an application programming interface (API). This provides a platform for others to build on, with many already looking to take the next step, such as Ben Goldacre’s new Open Trials initiative.
However, in order for this to work, we must capture as many articles and trials as possible to create a truly comprehensive thread of publications. We currently have data from the NIHR Libraries, PLoS and, of course, BioMed Central, but need more publishers and journals to join us in depositing clinical trial metadata. After all, without metadata, this is all merely wishful thinking.
Let’s hope we’re the pebble that starts the landslide.
